Pebble smartwatch stops by FCC, tries to prove it's not vaporware

The Pebble smartwatch missed its original September target ship date. Then, it failed to ship in time to stuff stockings this holiday season. And, while we've seen them in person and the company claims a release is imminent, you'd be forgiven for being a bit skeptical. But there is reason to hope: the connected wristwear has officially received a thumbs up from the FCC. What's more, the E-ink timepiece gets the full teardown treatment and comes complete with an owners manual. There's no surprises here, but if you're the impatient type, there should be a few things to keep you occupied until the next delay.

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Update on my health | Business Networking | Dr. Ivan Misner

As many of you know who follow my blog (regarding my health), I have been diligently working to regain my health for the past 9 months. ?I would like to give you another update, the best one yet! ?Recently my urologist requested PCA3 Assay test to determine the likelihood that I would once again have a positive biopsy.? This is a new test just approved by the FDA.? My doctor was intrigued with the ?fading? quality of the lesion as seen the in color Doppler ultrasound scans once I started the GC-18000 protocol with Dr. Grinstein in the UK.? Dr. Grinstein?s protocol had a swift and dramatic impact on the disease.

The results of the PCA3 Assay test came back last week with a low score (far lower than the urologist expected). ?The physician told me it seems that I am in remission! ?This was certainly great news to get as we started the holiday season. I personally attribute this shift to the dietary and lifestyle changes I have made under the supervision of? Dr. Mark Labeau with the Center for Advanced Medicine, as well as to the work of Dr. John Grinstein.? Dr. Grinstein?s understanding of cellular DNA damage and repair of that damage through plant-molecular biology has been extremely beneficial.

Feel free to contact them if you know someone with similar health issues.

I would like to wish you and yours a very Happy New Year and a very healthy and successful 2013 to us all!

Source: http://businessnetworking.com/great-news-on-my-health/

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Josh Brolin Talks Spike Lee's Oldboy

Building steadily for the past year, assembling a stellar cast including Elizabeth Olsen, Sharlto Copley, Samuel L. Jackson and James Ransone (one of our 10 Undervalued Actors Who Deserve To Get More?Work), production on Spike Lee's remake of Park Chan-Wook's outstanding "Oldboy" finally began in October. However, word since then has been relatively quiet, but leading man Josh Brolin has offered his take on the project and the people surrounding it.

While promoting the upcoming actioner ?Gangster Squad? this past Friday, Brolin was questioned about the remake of the 2003 original, and he confirmed his work on the film is finished, and also offered a note on his early experience. Claiming initially to ?have thought, 'Uh-oh, this could be a stinker' ? due to Lee's reportedly unconventional and ultra-violent approach to the material, he nonetheless regained his confidence by the end of filming and voiced his support for the ?fantastic? director, as well as a few other talents in the cast and crew. He said he was ?blown away? by Elizabeth Olsen, and also singled out Sean Bobbitt, who shot Steve McQueen's ?Hunger? and ?Shame,? as an ?unbelievable? addition to the team.

The actor also addressed the question of the faithfulness of the picture to either Chan-Wook Park's film or Garon Tsuchiya's manga, saying the movie shares similarities to the first "Oldboy" ?only in its structure.? He then added, ?It's more of an interpretation than it is a remake. I called Park Chan-Wook myself and I asked him, 'You know, I need your blessing in order to do this, because I won't do this without your full support.' He said, 'Absolutely, just don't do the same movie,' and we're not. I think it's going to turn out brilliant.?

If not brilliant, Brolin's intriguing hints promise at the very least another singular work from Lee, one ?that will be finally made visible when FilmDistrict brings ?Oldboy? to theatres on October 11, 2013.

Source: http://www.rottentomatoes.com/m/1926501/news/1926501/

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Reproduction and life span are intertwined

Dec. 17, 2012 ? The gonad is well known to be important for reproduction but also affects animal life span. Removal of germ cells - the sperm and egg producing cells - increases longevity of the roundworm Caenorhabditis elegans. However, the underlying molecular mechanisms were a mystery. Now scientists at the Cologne-based Max Planck Institute for Biology of Ageing, have discovered that germ cell removal flips a "molecular switch" that extends the life span by using components of a "developmental clock."

The roundworm Caenorhabditis elegans is a commonly used model organism in the field of aging research. It develops from an egg to adult through four larval stages. These developmental stages are controlled by a developmental clock. Yidong Shen and colleagues working in the department of Director Adam Antebi used a laser to remove the germ cells.

They found that the remaining gonadal cells trigger production of a steroid hormone called dafachronic acid. Dafachronic acid activates so-called microRNAs, which work as tiny molecular switches causing changes in gene expression that promote longevity. Interestingly, this same steroid hormone-microRNA switch was previously shown by Antebi and colleagues to be part of the developmental clock. Thus, the loss of the germ cells ultimately causes the worm to use developmental timers to put in motion a life-prolonging programme.

In uncovering these findings, the Max Planck scientists have added some more pieces to the puzzle of describing and understanding how longevity is regulated. The question now is whether humans also possess a similar microRNA-controlled switch system.

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Story Source:

The above story is reprinted from materials provided by The Max Planck Institute for Biology of Ageing/ Max-Planck-Institut f?r Biologie des Alterns.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Y. Shen, J. Wollam, D. Magner, O. Karalay, A. Antebi. A Steroid Receptor-MicroRNA Switch Regulates Life Span in Response to Signals from the Gonad. Science, 2012; 338 (6113): 1472 DOI: 10.1126/science.1228967

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/pSJqYl5EpP8/121217091157.htm

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